It’s holiday season and regardless of what you celebrate, one thing is certain: amid the merriment, stress abounds! We’re all familiar with the headaches of crowded airports, panic of last-minute gift shopping and ever present potential for family dramas to play out like crazed telenovelas. Combine all of that with a seemingly endless supply of temptation in the form of alcohol and sugary treats and it’s nothing short of a firestorm for two biomarkers, testosterone and cortisol — and the golden ratio between them!
Just how important are these two biomarkers? The experts here at InsideTracker have been blogging about testosterone and cortisol for some time now, and you can dive more into each here (testosterone) and here (cortisol).
As a quick refresher, these are the key points:
- Testosterone isn’t just for the boys. It plays a critical role in health and performance for both men and women.
- In both men and women, to different degrees, testosterone affects muscle mass, strength, recovery, bone health and of course, sex drive.
- 2-3% of the hormone exists in its “free”, unbound state, called free testosterone (FT) and in its “bound” state. The combination of free and bound testosterone is called total testosterone (TT). Both are measured in our Ultimate panel, of course.
- Despite its reputation, cortisol is actually needed by our bodies to carry out essential functions, like breaking down energy for use in a workout. It also keeps the immune system in check.
- Short-term, elevated cortisol levels are healthy.
- Chronically elevated cortisol levels are unhealthy and contribute to: high blood-sugar, depression, weak immunity, heart disease, high blood pressure, increased body fat, poor cognition and focus
About the Ratios: testosterone to cortisol
Now that you’re all brushed up on why it’s critical to maintain the right balance of each of these hormones, let’s get to the good stuff: The Golden Ratio, aka testosterone to cortisol (T:C). Recently, we uncovered research showing that this ratio can unveil even more important information about our health than either biomarker alone. This ratio can reveal information about athletic performance, mental wellness, and overall heart health. It exists in two different forms — the free testosterone to cortisol ratio, referred to as FT:C, and the total testosterone to cortisol ratio, for the purposes of this article referred to as T:C.
A key indicator of athletic performance
The free testosterone to cortisol ratio (FT:C) is highly-valued by sports scientists and fitness buffs as a tool in determining if the body is getting sufficient rest from exercise. In 1995, researchers identified the testosterone/cortisol ratio as an indicator of the amount of strain on the body during exercise. They noted that this ratio “decreases in relation to the intensity and duration of physical exercise, as well as during periods of intense training or repetitive competition.” Additionally, they noted that the ratio serves as a strong indicator of “physiological strain” during training. In a follow up 2002 paper, they stated that the “ratio between (free) serum testosterone and cortisol, may serve to reveal circumstances which, for the long term, impair the exercise performance.”
Several studies support the theory that FT:C ratio is an indicator of physical strain. In the nine months prior to the 1988 Olympics, a group of researchers tracked six male rowers preparing for the Games. When comparing athletes’ FT:C ratios through the season with their levels prior to training, results showed that periods of intense training led to the biggest decrease in the FT:C ratios in the rowers. On the flipside, the FT:C ratio increased to its highest levels during periods of lower intensity training.
This suggests that you are likely to see an increased FT:C ratio after strenuous exercise. So it’s probably best not to have your blood tested right after exercise. However, if the FT:C ratio shows up as low after 24 hours of exercise, you may not be getting sufficient recovery and rest.
Key Takeaways: A low free testosterone to cortisol ratio may indicate insufficient recovery after exercise.
Recommendations: If you are concerned about recovery after intense exercise, use InsideTracker analytics to learn your FT:C ratio. Remember to rest for at least 24 hours after exercise to get the most accurate results. If your FT:C ratio is too low, consider using InsideTracker recommendations to get it in the optimal zone.
Influence on heart health
A lot of research on the total testosterone to cortisol ratio (T:C) has looked its impact on athletic performance. However, because both testosterone and cortisol are critical indicators of overall health, researchers have begun to assess what else the T:C ratio can tell us.
In one 2005 study, researchers observed that a lower ratio of T:C was associated with greater levels of insulin resistance. Insulin resistance can lead to a variety of complications such as type II diabetes and heart disease. Additionally, a lower T:C ratio was also associated with an increased chance of developing ischemic heart disease (IHD), a heart condition in which arteries harden and prevent oxygen from entering the heart — and is the leading cause of death in developed nations.
Data from Smith et. al
Some researchers have surmised that a lower T:C ratio is associated with a lower heart rate variability (HRV), the difference in time between heart beats. One highly-regarded paper indicates that a lower HRV is associated with an increased chance of heart attack. While more rigorous research needs to be done to evaluate this relationship, it’s safe to say that the T:C ratio may be a more powerful indicator of heart health than either cortisol or testosterone independently.
Key Takeaways: A low T:C ratio is associated with an increased risk of developing heart disease, the number one killer in the US and developed world. Some researchers indicate that a high total T:C ratio may also be linked with a lower HRV, the variation in time between heart beats, which in turn is linked to increased risk of heart attack.
Recommendations: Measure your T:C ratio using InsideTracker. Then, use interventions such as resistance training that increase the T:C ratio.
Too much of a good thing... can testosterone be too high?
So far, we have only talked about cases where a higher T:C ratio is beneficial to athletic performance and health. However, research in mental health indicates that an unusually high T:C ratio may also have some drawbacks.
Culturally, we associate testosterone with aggression and impulsive behavior. And there is some truth to this: recent research suggests that high testosterone can lead to conditions associated with high social aggression. In a 2009 study it was noted that while high levels of testosterone and low levels of cortisol were independently associated with aggressive behavior in social contexts, the T:C ratio seemed to be a particularly strong indicator of social aggression. Other studies have also indicated this, in both men and women.
The T:C ratio may tell us critical information about mental health that each biomarker alone does not provide.
Relation between the ratio of baseline testosterone to cortisol reactivity and psychopathy at high and low values of baseline testosterone. From Glenn et. al
So, what does this research mean for you? Basically, there can be “too much of a good thing.” Even though increased testosterone helps sex drive, athletic performance, and lowers your risk for chronic diseases, if elevated to unhealthy levels it can lead to overly-aggressive behavior and potentially trigger the development of disruptive mental conditions such as psychopathy. Thus, it is critical to monitor testosterone, cortisol, and T:C ratios to make sure they are in their optimal zones. This is especially important if you are currently considering testosterone replacement therapy.
Key Takeaways: Some research indicates that a high testosterone to cortisol ratio is associated with socially aggressive behavior and mental conditions such as psychopathy and antisocial personality disorder.
Recommendations: If you are trying to increase your testosterone to cortisol ratio, use InsideTracker’s blood analysis to make sure that it doesn’t elevate to unhealthily high levels. InsideTracker can provide recommendations to lower your T to C ratio if it becomes too high.
Putting it all together
Science says that cortisol and testosterone each tell us important things about our overall health and fitness. Some science suggests that the testosterone to cortisol ratio (T:C) may unearth even more key information about your body and mental health. More specifically, a low free testosterone to cortisol ratio (FT:T) may tell you that you’re not getting enough recovery after training and increase your risk of developing heart disease. On the flipside, an unhealthily elevated T:C ratio can tell you about the risk of developing a mental health condition characterized by overly aggressive behavior.
InsideTracker allows you to uncover these critical ratios, along with data on many other health-related biomarkers. When you have your data and the proper, research-based interventions, you can start making the most impactful changes to set you on the path to optimal health, performance, and well-being.
Wondering what ALL of your biomarkers mean? We've created this FREE biomarker e-book for reference—it's yours to download!
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1. Emadi-Konjin, Pasha, Jerald Bain, and Irvin L. Bromberg. "Evaluation of an algorithm for calculation of serum 'bioavailable' testosterone (BAT)." Clinical Biochemistry 36.8 (2003): 591-596.
2. Simon, Dominique, et al. "Association between Plasma Total Testosterone and Cardiovascular Risk Factors in Healthy Adult Men: The Telecom Study 1." The Journal of Clinical Endocrinology & Metabolism 82.2 (1997): 682-685.
3. Wickramatilake, Chandima Madhu, Mohamed R. Mohideen, and Chitra Pathirana. "Association of metabolic syndrome with testosterone and inflammation in men." Annales d'Endocrinologie. Elsevier Masson, 2015.
4. Westley, Christopher J., Richard L. Amdur, and Michael S. Irwig. "High Rates of Depression and Depressive Symptoms among Men Referred for Borderline Testosterone Levels." The Journal of Sexual Medicine (2015).
5. Chung, Kyung-Jin and Khae-Hawn Kim. "Forbidden fruit for athletes, but possible divine blessing for rehabilitation: testosterone." Journal of Exercise Rehabilitation 11.1 (2015): 2.
6. Lupien, S. J., de Leon, M., De Santi, S., Convit, A., Tarshish, C., Nair, N. P. V., & Meaney, M. J. (1998). Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nature Neuroscience 1(1), 69-73.
7. Chandola, Tarani, Eric Brunner, and Michael Marmot. "Chronic stress at work and the metabolic syndrome: prospective study." BMJ332.7540 (2006): 521-525.
8. Palacios, Gonzalo, et al. "Biomarkers of physical activity and exercise." Nutr Hosp 31.Supl 3 (2015): 237-244.
9. Urhausen, Axel, Holger Gabriel, and Wilfried Kindermann. "Blood hormones as markers of training stress and overtraining." Sports medicine 20.4 (1995): 251-276.
10. Urhausen, Axel, and Wilfried Kindermann. "Diagnosis of overtraining." Sports medicine 32.2 (2002): 95-102.
11. Vervoorn, C., et al. "The behaviour of the plasma free testosterone/cortisol ratio during a season of elite rowing training." International journal of sports medicine 12.3 (1991): 257-263.
12. Adlercreutz, Herman, et al. "Effect of training on plasma anabolic and catabolic steroid hormones and their response during physical exercise."International journal of sports medicine 7 Suppl 1 (1986): 27-8.
13. Urhausen, A., T. Kullmer, and W. Kindermann. "A 7-week follow-up study of the behaviour of testosterone and cortisol during the competition period in rowers." European journal of applied physiology and occupational physiology56.5 (1987): 528-533.
14. Jurimāe, J., T. Jurimāe, and P. Purge. "Plasma testosterone and cortisol responses to prolonged sculling in male competitive rowers." Journal of sports sciences 19.11 (2001): 893-898.
15. Smith, George Davey, et al. "Cortisol, testosterone, and coronary heart disease prospective evidence from the Caerphilly Study." Circulation 112.3 (2005): 332-340.
16. Murray, Christopher JL, et al. "Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013." The Lancet 384.9947 (2014): 1005-1070.
17. Kleiger, Robert E., et al. "Decreased heart rate variability and its association with increased mortality after acute myocardial infarction." The American journal of cardiology 59.4 (1987): 256-262.
18. Terburg, David, Barak Morgan, and Jack van Honk. "The testosterone–cortisol ratio: A hormonal marker for proneness to social aggression." International journal of law and psychiatry 32.4 (2009): 216-223.
19. Hare RD. Hare Psychopathy Checklist-Revised (PCL-R): 2nd Edition. Toronto: Multi-Health Systems, Inc; 2003.
20. Glenn, Andrea L., et al. "Increased testosterone-to-cortisol ratio in psychopathy." Journal of abnormal psychology 120.2 (2011): 389.
21. Platje, Evelien, et al. "Testosterone and cortisol in relation to aggression in a non‐clinical sample of boys and girls." Aggressive behavior (2015).