What Happens to Your Body When You Sit All Day, with Dr. Keith Diaz

By Gil Blander, PhD, August 20, 2025

 

Listen to this episode of Longevity by Design on Apple Podcasts, Spotify, and YouTube

86dxbvjv9 - Inside Tracker - Longevity by Design - Dr. Keith Diaz - Website Thumbnail
In this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Keith Diaz, Associate Professor of Behavioral Medicine at Columbia University Irving Medical Center, to unpack the hidden health risks of prolonged sitting.


Keith explains why even daily exercise isn't enough to counteract the effects of sedentary behavior. Drawing on his lab's findings, he shares a simple but powerful prescription: five minutes of light walking every hour. That small change can lower blood pressure, improve mood, and reduce fatigue, without needing to break a sweat.


The conversation also explores how modern work and home environments are built around sitting, and what it takes to build smarter habits. From treadmill desks to family walks, Keith offers practical strategies that make movement part of everyday life. Whether you're an employer, a clinician, or just desk-bound, this episode helps you rethink how you move through your day.

 

Guest-at-a-Glance

💡 Name: Dr. Keith Diaz

💡 What they do: Associate Professor

💡 Company: Columbia University Irving Medical Center

💡 Noteworthy: Leading researcher on sedentary behavior, cardiovascular health, and wearable tech in clinical care.

💡 Where to find them: LinkedIn

 

Episode highlights:


[00:00:00] Introduction: The Evolution of Television Viewing Habits
[00:00:23] Welcome to Longevity By Design
[00:00:33] Introducing Dr. Ki Diaz
[00:02:14] The Impact of Sedentary Behavior
[00:04:23] The Physiology of Sitting
[00:09:59] Exercise vs. Sedentary Lifestyle
[00:16:56] Movement Breaks: How Short is Beneficial?
[00:27:45] The Role of Wearable Devices
[00:31:51] Integrating Movement into Daily Routines
[00:33:34] Behavioral Changes and Personal Strategies
[00:34:55] The Benefits of Movement Breaks at Work
[00:37:26] Wearables and Their Impact on Health
[00:40:16] Clinicians' Role in Promoting Movement
[00:43:09] Tailoring Movement to Individual Lifestyles
[00:47:28] Incentives for Employers and Insurers
[00:52:46] Personal Movement Hacks and Daily Routines
[00:58:16] Future Research and Final Thoughts




Key Insights

Sitting Isn't Just "Not Moving"—It Actively Harms the Body

Most people think of sitting as neutral—something that just happens when you're not being active. But Keith Diaz's research shows that sitting for long periods can disrupt important body functions. Muscles stop contracting, reducing their ability to manage blood sugar and fat levels. Blood flow becomes restricted, especially in the legs, increasing pressure and creating turbulence that damages blood vessels. These effects can happen even in people who exercise daily, suggesting that prolonged sitting isn't just the absence of movement—it creates its own negative health outcomes. The longer and more consistently you sit, the more damage is done over time. That's why Diaz stresses breaking up sitting as often as possible. It's not just about moving more; it's about sitting less continuously.


Small Movement Breaks Can Have Big Health Benefits 

You don't need to hit the gym to reduce the damage of sitting. Just five minutes of light walking every hour can improve blood pressure, mood, and energy levels—benefits nearly equal to more intense workouts. Even one-minute walks help, though they're less effective. Keith's lab found that these short, simple interventions can reduce blood sugar spikes after meals by as much as 60%, which rivals the effectiveness of some medications. Importantly, the pace doesn't need to be fast. The key is frequent, low-intensity movement that activates muscles and restores blood flow. Whether it's walking during meetings, stepping in place at your desk, or choosing a far-away restroom, consistent breaks matter. For desk-bound professionals, this redefines what it means to stay healthy at work.


Wearables Can Nudge but Don't Replace Behavior Change

Fitness trackers can help people recognize how sedentary they've become, especially since many of us have learned to ignore our body's cues to move. Reminders, buzzes, and nudges work best as temporary training wheels—not permanent solutions. Many users eventually silence them because they're disruptive or poorly timed. Keith suggests smarter prompts—like syncing movement reminders with calendar breaks—and ultimately building movement into your natural daily rhythm. Using meetings, phone calls, or task switches as cues for walking breaks helps form sustainable habits. Wearables are powerful for raising awareness and tracking goals, but lasting change happens when people redesign how they move through the day—not just how their devices buzz.


Workplaces and Schools Need a Culture Shift Around Movement

One of the strongest themes in the conversation is the need to normalize movement—not treat it as a disruption. Today's workplaces are built around sitting, and schools teach children to suppress natural urges to move. That conditioning follows us into adulthood. Keith argues that movement should be treated as essential to health and productivity, not as a distraction from it. Studies show that regular movement breaks improve focus, creativity, and executive function. Employers and clinicians have a role to play: encouraging breaks, redesigning physical spaces, and reframing movement as a tool for better performance. Movement isn't just good for longevity—it's good for business, brainpower, and everyday function. Reversing the sitting epidemic starts with changing the default.

 

Rethinking the Roots of Sedentary Culture

Keith explores how technology, urban design, and lifestyle changes have made sedentary behavior the default in modern life. From transportation to meal prep to how we work, our environment rewards stillness. Keith explains that it's not just about individual choices—society itself has shifted to encourage prolonged sitting. He also highlights how even leisure time has changed, with screen-based entertainment replacing more active forms of recreation. This framing sets up the urgency for rethinking how we build movement back into daily life—not just as exercise, but as a baseline human behavior.

“Our world is changing with all the technological innovations we've seen in the last 50—100 years. It's just pushing our societies to spend most of our days sitting. While I'm sitting here talking to you, a million things could be happening now. I have a vacuum self-cleaning the floor. My washing machine could be running, washing my clothes.”



Standing Desks vs. Real Movement

Keith tackles the common question: Do standing desks actually improve health? While popular, the research around standing desks remains inconclusive. Some studies show benefits, while others suggest potential harm to leg circulation. Keith doesn't outright dismiss them, but he's clear that standing isn't a substitute for movement. Instead, he encourages listeners to prioritize walking breaks and active workstations, which have more consistently demonstrated health benefits in lab settings. The goal isn't to eliminate sitting—it's to mix it with meaningful movement.


"My answer usually is: we know definitively that moving is better than sitting. So if you were to try to figure out what to do—standing desk versus just trying to find a way to get some movement breaks in—I would lean toward encouraging everybody to find a way to get more movement breaks in.”

 

Building Habits Around Movement, Not Just Tracking

While wearables can raise awareness, Keith explains that long-term behavior change happens through rhythm, not reminders. He discusses how people quickly tune out device prompts and why timing matters—being nudged in the middle of a meeting just creates friction. Instead, he suggests tying movement to the natural breaks in your schedule—after meetings, during calls, or while refilling water. These habit loops create lasting change. Movement becomes automatic, not another task to remember. Wearables have value, but they're most effective when used to build structure into your day—not dictate it.


"People hate those buzzers and those prompts over time, and most people turn them off after a while. They just become annoying. And they're not what I call smart nudges. I don't want to be nudged when I'm in the middle of a work meeting and can't get up to take a movement break in the middle of it. The aspiration here is to make this like brushing teeth—something that just becomes part of your routine.”

 

 

A Case for Changing School Systems

In one of the most thought-provoking segments, Keith shares where he believes the sitting problem begins: childhood. He argues that schools unintentionally train kids to suppress natural movement, encouraging long periods of sitting from a young age. This behavior gets hardwired and carries into adulthood. Instead, classrooms should support fidgeting, standing, and movement—normalizing those behaviors early. His “magic wand” intervention wouldn't target adults first—it would start by redesigning school environments. That's how we prevent future generations from internalizing stillness as the norm.


"I would change our school systems to be designed not to make kids sit all day. I would design classrooms that were more natural, allowing kids to stand, move, fidget - whatever - and let them naturally move their bodies as the classroom would allow, not just constrain them to be in their chairs." 

 

 

 

 

For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast

 

Similar Longevity By Design episodes we think you would love: 

 


LBD_brandtile_2

Longevity by Design

Longevity by Design is a podcast for individuals looking to experience longer, healthier lives. In each episode, Dr. Gil Blander and Ashley Reaver join an industry expert to explore a personalized health journey. The show helps you access science-backed information, unpack complicated concepts, learn what’s on the cutting edge of longevity research and the scientists behind them. Tune into Longevity by Design and see how to add years to your life, and life to your years.

8 Ways to Biohack Your Health

Free eBook

eBook_img

More on this topic

New call-to-action